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Other mechanisms These include, among others, changes in the intestinal microbiota, in the glucose and insulin gradient of the porto-systemic axis, and in the action of GLP-1 on vagal afferents, as well as a reduction in endogenous glucose production12, and an increase in bile salts and intestinal glucose absorption due to increased expression of sodium-glucose cotransporter type 1 (SGLT1)7,1315

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When starting semaglutide (a GLP-1 agonist), some people may notice a slight reduction in weight during the first week, though the changes tend to be modest

Patients may also experience associated symptoms such as hoarseness, chronic cough, or a feeling of a lump in the throat