semaglutide health canada approves first GLP-1 pill for high-risk type 2 diabetes patients Aspen Pharmacare wins Canada approval

Weight loss typically ranges from 15 to 20 percent, with HbA1c reductions around 1.5 percent

The landmark PREDIMED trial -- a randomized controlled trial involving 7,447 participants -- demonstrated that a Mediterranean diet supplemented with EVOO (approximately 50 g/day) did not result in weight gain over nearly five years of follow-up, despite being an unrestricted-calorie, high-fat diet (Estruch et al., 2018)

Severe pancreatitis can lead to life-threatening complications and requires hospital care

Once retatrutide is approved in the UK, a switch would normally involve stopping Mounjaro, a washout of around four to six weeks, and starting retatrutide at the lowest dose with slow titration