Additional preclinical work published in Cell Chemical Biology evaluated NNMT inhibition in similar diet-induced obesity models and confirmed the pattern: significant reductions in body weight gain, adipose tissue expansion, and circulating triglycerides compared to untreated controls
Extended exposure to this anticholinergic drug may impair cognitive function over time, elevating the risk of developing neurodegenerative conditions in susceptible individuals
Therefore, although the intestinal microbiota of HT patients has changed, whether it is to help the host fight against or promote disease needs more animal experiment to prove
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