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10.1161/01.CIR.0000055331.41937.AA Circulation 187 TrusolinoL.BertottiA.ComoglioP

Phase 1: Retatrutide foundation (weeks 1-8) During this initial phase, the goal is to establish retatrutide tolerance before adding cagrilintide

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In parallel, advances in peptide chemistry and structural biology have enabled the design of aggregation inhibitors, receptor-selective neuropeptide analogues, and cell-penetrating or brain-targeted peptide conjugates that modulate key pathways, including proteostasis, insulin and incretin signaling, neurotrophic support, and microglial activation