Experimental models include isolated perfused hearts (Langendorff), ex vivo working heart preparations, in vivo echocardiography with metabolic phenotyping, transgenic models affecting carnitine metabolism (OCTN2 knockout, CPT-I variants), and large animal models of myocardial infarction
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10,14 The light, modifier subunit provides a regulatory function, while GCLC is responsible for the catalytic activity, which conjugates sulfur-containing cysteine with glutamate, forming -glutamylcysteine
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