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LinkedIn built the ranking by looking at two things: how fast hiring and job postings are growing in a metro relative to its size, and whether more LinkedIn members are moving in than out

In a meta-analysis of CVOTs, the 5-year absolute risk reduction (ARR) in MACE with SGLT-2 inhibitors compared to placebo was 1.8% in people with established atherosclerotic CVD, and 0.8% in those with multiple cardiovascular risk factors only [18]

Others find that aligning their injection day with their most active days of the week produces better outcomes

However, the EMPA-REG OUTCOME trial with empagliflozin, the DECLARE-TIMI 58 trial with dapagliflozin, and the VERTIS CV trial with ertuglifozin did not report an increase in amputations in the patients treated with an SGLT2 inhibitor (143,156,160,230)