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As a result, potential safety concerns might arise in everyday clinical practice that were not evident during the more controlled and structured environment of clinical trial evaluations [Reference Paludetto, Olivier-Abbal and Montastruc28]
Attenuation of glomerular hyperfiltration results in prevention of long-term glomerular damage, contributing to reduce the progression of diabetic kidney disease (DKD) ( Figure 1 The increased sodium delivery to the macula densa theoretically results in low renin levels per se
Many steroids convert to estrogen through the aromatase enzyme, producing water retention, potential gynecomastia, and a softer appearance that contradicts recomposition goals
Close monitoring of blood glucose levels is essential during the first month of combination therapy
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