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Decreased DA neuron activity in VTA is associated with depression-related behaviors ( Changes in levels of various cytokines, which have potential effects on neurotransmitter metabolism, have been widely observed in the thyroid and orbital tissues of GD patients ( Subsequently, the alteration of these cytokines is involved in the disruption of monoamine neurotransmitters, including serotonin (5-HT), dopamine (DA), and norepinephrine (NE) ( As neurotransmitters play a critical role in the function of the central nervous system, the disrupted metabolism of monoamine neurotransmitters can increase the risk of depressive behaviors
Randomized controlled trials have shown that as complementary treatments, fucoidan and luteolin can effectively improve the quality of life of terminal cancer patients after undergoing radiotherapy or chemotherapy (Takahashi et al., 2018
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