retatrutide diabetes type 1 Retatrutide—A Game Changer in Obesity Pharmacotherapy Substack Series 3 of 6:

Starting at $349.99 /mo Mounjaro A once-weekly tirzepatide injection that activates two hormone receptors GIP and GLP-1 to reduce appetite, slow gastric emptying, and support metabolic health

| How these medications work | Head-to-head clinical evidence | Side effects and tolerability | Practical differences | Cost and access in the UK | Who might prefer each option

Some practitioners recommend 4-6 week breaks every 6-12 months to assess natural function and prevent potential receptor downregulation, though long-term studies show sustained efficacy

Efficacy and safety of retatrutide (TRANSCEND-T2D-1): a double-blind, randomised, phase 3 trial