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"Efficacy and safety of dulaglutide versus sitagliptin after 52 weeks in type 2 diabetes in a randomized controlled trial (AWARD-5)"

GLP-1 medications mimic a natural hormone that slows stomach emptying and reduces appetite

Through these additional endocrine affects, the synthetic GHS peptides also markedly increase appetite and weight gain, modulate cell proliferation and survival, are cardioprotective, affect heart performance and vascular resistance, are immuno-supportive and anti-arthritic, influence gastric acid secretion and motility, energy/glucose metabolism, as well as exocrine and endocrine pancreatic function

Su funcin es incrementar la secrecin de insulina, retrasar el vaciamiento gstrico y reducir las seales de apetito a nivel cerebral