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However, it remains unclear whether copper accumulation in senile plaques of AD patients is a cause or a consequence of pathological processes observed in AD

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revealed that the use of a novel REDOX selective APE1 inhibitor in vitro and in vivo could effectively reduce the progression of bladder cancer, and the combination of this inhibitor with cisplatin, a commonly used chemotherapy drug, was more effective than cisplatin alone [26]

The work included experiments in both humans and mice, along with analyses of data from clinical trials involving diabetes medications