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Inflammatory macrophages are the major contributor to necrotic core formation, yet TREM2+ macrophages have recently been shown to have low expression of inflammatory genes and a beneficial role in atherosclerosis 97,98,99,100,101,102

When permeabilised INS-1 cells, perfused with an elevated fixed concentration of Ca 2+ and ATP, were exposed to a high concentration of glucose, insulin secretion was stimulated, accompanied by an increased intracellular glutamate concentration [67]

doi: 10.1016/S0950-3579(05)80113-X 51 AthanassakisIMouratidouMSakkaPEvangeliouASpiliotiMVassiliadisS

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