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Aging Cell 23 , e14138 (2024)

Oxidative stress, which is initiated by free radicals (FR) and reactive oxygen species (ROS) promoting lipid peroxidation and oxidation of GSH to form GSSG, contributes to the reduction of this important molecule and the change in the ratio of GSH/GSSG of 100:1 to 10:1 or even 1:1 (Pastore et al