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Tirzepatide: Dual GIP/GLP-1 Receptor Agonist Tirzepatide activates two receptor types simultaneously: GLP-1: Same appetite suppression and insulin-stimulating benefits as semaglutide GIP (Glucose-dependent insulinotropic polypeptide): Improves insulin sensitivity, influences fat metabolism, and may change how the body responds to nutrient intake GIP receptor activation is what sets tirzepatide apart