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For procedures in which complications are catastrophic, including TJA, counseling should prioritize discontinuation of nonessential injectable biologics before surgery, explicit documentation of exposure, and heightened vigilance for early wound complications

Current evidence suggests that blanket supplementation recommendations may be insufficient, and future clinical practice should embrace individualized dosing strategies based on patient-specific characteristics and therapeutic goals

Binding to TSPO is also inversely correlated with gray matter volume and performance on measures of cognitive function in all patients with AD

doi:10.1210/edrv-14-1-107 [2] Hu S, Rayman MP