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Gastrointestinal effects likely contribute substantially to taste perception changes

The most commonly reported adverse effects are gastrointestinal in nature and include: Nausea (particularly during dose escalation) Vomiting Diarrhoea Constipation Decreased appetite These effects are generally dose-dependent and tend to be most pronounced during the initial weeks of treatment when the dose is being gradually increased

In other studies, 100 mg or more of cardiac tissue was used as starting material for a phosphoproteomics analysis