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Significantly, melatonin supplementation has demonstrated the capacity to alleviate oxidative stress and impede the accumulation of A, as well as tau hyperphosphorylation, in the hippocampus of aged rats exhibiting brain insulin resistance induced by a high-fat diet [135]

490 Fang found DOX increased Nrf2 nuclear accumulation, promoted the expression of HO-1, and caused heme degradation, and led to the rapid and systematic accumulation of free non-heme iron

Lack of sleep: Nighttime is the bodys key period for recovery and repair processes