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Mechanisms: Stimulates chondrocyte activity and enhances extracellular matrix production in cartilage

It is common for patients to continue taking the medication for multiple years, even once their goal weight has been achieved, just to make sustaining the weight loss more manageable

In this context, fibroblast growth factor 21 (FGF21) analogues are attractive because they target multiple components of MASH biology simultaneously, with potential to improve steatosis, inflammation, fibrosis, and broader cardiometabolic risk

IGF-1 is the anchor metric community sources describe a 20-40% increase from baseline as the sign the protocol is working even when visual changes are minimal