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At therapeutic doses it is safe for most people, but acetaminophen metabolism uses glutathione directly, and chronic high dose use is the leading cause of acute liver failure in the United States precisely because it exhausts hepatic glutathione (PubMed PMID: 26041729)
10a, b) indicating a damaging effect on the barrier function of the cell layers
This study was supported by FAR2024PD (#E93C24000570005) to FB and by PRD2026 from the Department of Life Sciences, University of Modena and Reggio Emilia, Italy (FB)
Raw consumption preserves the highest glutathione levels, but light steaming, quick sauting, or stir-frying can retain significant amounts while making other nutrients more bioavailable
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