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Cardiometabolic disease is used as an umbrella term for all the above cases, and severity of cardiometabolic disease refers, in this manuscript, to the progression from single risk factors such as obesity to overt T2D and cardiac phenotype (ischemic heart disease and heart failure)

Gastrointestinal applications warrant symptom diaries, quality of life measures, and endoscopic assessment when indicated

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The review may include vaginal dryness, pain during intimacy, changes in sensation, hormone-related concerns, or a difference in overall responsiveness