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More than one in eight participants on retatrutide were completely free from knee pain at week 68, compared with 4.2% in the placebo group

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High-intensity interval training significantly increased p-AMPK/-actin, p-AMPK/AMPK, and p-AMPK/COX-IV ratios, and upregulated Beclin-1, LC3-II, Parkin, PINK1, PGC-1, and p70S6K protein levels and LC3-II/LC3-I ratio