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PMID: 14988435 Shuster S, Black MM, McVitie E
569 developed PROTAC for targeting SRC1 through N-degron pathway in vivo, suggesting the usefulness of N-degron pathway-based degraders of disease-relevant proteins
Fractional lasers create tiny microscopic treatment zones in the skin, leaving surrounding tissue intact to speed healing and drive collagen remodelling
ACPs design strategies, such as hybridization, cyclization, modification, and fragmentation, can potentially improve the therapeutic efficacy by extending the half-life time of medications in plasma, boosting activity, and minimizing drug toxicity (154)
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