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BMC Clinical Pharmacology

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Drug Resistance of Pituitary Tumors: Molecular Mechanisms Despite the demonstrated inhibitory effects on cell proliferation and hormone secretion of DA and SS analogs, a subset of patients (10% of patients with prolactinoma and 30% of acromegalic patients) are resistant to cabergoline and octreotide, respectively, while the large majority of patients with NFPA and ACTH-secreting pituitary tumors are unresponsive to both drugs (1517)

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