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A randomized, double-blind, placebo-controlled trial in 60 healthy older adults (mean age, 68.5 years) investigated whether acute (80 mg) or chronic (80 mg/day for 4 weeks) oral intake of curcumin could improve their ability to cope with the mental stress and change in mood usually associated with undergoing a battery of cognitive tests (97)

Even this narrow decrease in Se net intake caused the alteration of 952 genes expression 772 genes were down-regulated and 230 genes were found to be up-regulated

A meta-analysis including five randomized controlled trials (RCTs) and ten prospective non-RCTs statistically demonstrated the benefits of selenium supplementation in preventing KBD in children 75

[DOI] [PMC free article] [PubMed] [Google Scholar] 118.Junqueira C., Crespo ., Ranjbar S., Ingber J., Parry B., Ravid S., de Lacerda L.B., Lewandrowski M., Clark S., Ho F., et al