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Retatrutide's triple receptor agonism offers theoretical and early clinical advantages, particularly in weight loss magnitude and hepatic fat reduction, but these benefits must be confirmed in Phase 3 trials

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In a cohort of 91 MM patients, 18% of cases show TSC1 loss-of-function mutations which plays a suppressive role in cellular proliferation initiated by mTOR (109) and a similar result also showed in a recently published meta-analysis review of MM (105)