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The heterodimer of amino acid transporter solute carrier family 7 member 11 (SLC7A11) and amino acid transporter solute carrier family 3 member 2 (SLC3A2) is the main component of the sodium-dependent cystine/glutamate transporter (systemX c ) localized on cell membrane (Koppula et al., 2021), which exchanges cystine and glutamic acid at a ratio of 1:1

Paradoxically, several pathways implicated in PD pathogenesisincluding glycogen synthase kinase-3 (GSK-3), p38 MAPK, and nuclear factor-B (NF-B)are upregulated and inhibit Nrf2 activity (Mogi et al., 2007