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Most participants discontinued the trial due to gastrointestinal issues (8 out of 10 cases)

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On top of that, exercise on its own can improve cardiovascular and bone health, so its never an either-or decision, Kushner says

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One older study found that small amounts of these compounds can pass through the skin from adhesive patches, but theres no evidence that this level of absorption translates into meaningful weight loss

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Sattar et al., 2021

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