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Checked baggage compartments can reach temperatures well below freezing during flight, which would destroy the medication

When patients lose weight on a GLP-1 receptor agonist and their blood pressure improves and their cholesterol gets better, the easy assumption is that the cardiovascular protection is just a downstream consequence of the weight loss

Neuropsychopharmacology 25 (2), 165172

However, GIP resistance, a complete loss of insulinotropic effect of GIP at physiological concentrations as well as supraphysiological concentrations was observed in people with T2D