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As such, GIP analogs were initially not pursued as monotherapies to treat diabetes or obesity due to the perception of an overall weak biological effect, in part because of early findings suggesting a GIP resistance in the diabetic condition (21) alongside incongruent results on its hypophagic and body weightlowering effects (19,2226)

Oxidative stress enhances NF-B-dependent activation of HIV transcription, thereby facilitating viral replication 117

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