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Moreover, a similar pretreatment reduced LPS-stimulated production of proinflammatory cytokines in BV-2 cells

Even when a small fraction does reach the viable epidermis, the molecule has a short functional half-life unless it is stabilized in the formulation (encapsulation, copper chelation, or both) 1

In Alzheimers disease models, it also upregulates endogenous antioxidative enzymes such as SOD and catalase, mitigating amyloid--induced oxidative injury ( Riboflavin further modulates redox-sensitive transcription factors including Nrf2 and AP-1, thereby inducing downstream antioxidant genes like NQO1, GCLC, and HO-1

Disclaimer: These statements have not been evaluated by the FDA