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There was no notable difference by baseline BMI category

However, their translation to clinical practice hinges on addressing critical gaps, including the need for rigorous human trials, long-term safety assessments, and mechanistic clarity

Additional information Publishers note: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations

Availability of data and materials The subject level analysis data sets for the research presented in the publication are available from the corresponding author on reasonable request