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2024;doi:10.1056/NEJMoa2403347) demonstrated that addition of semaglutide (Ozempic/Wegovy, Novo Nordisk) to an SGLT2 inhibitor showed no renal protective effect (HR = 1.07, 95% CI 0.69-1.67), although the number of subjects receiving an SGLT2 (16%) in this study was relatively small

They were also advised to discontinue oral vitamin A, C, and E supplementation

This pattern is consistent with a healthy-user bias, whereby individuals who are younger and generally healthier tend to experience more favorable outcomes regardless of treatment exposure