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Safety monitoring revealed mild gastrointestinal side effects like nausea, but no severe adverse events or negative fetal outcomes were attributed to GLP-1 exposure

Duncan notes

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In streptozotocin-induced diabetic mice, Ex-4 has been observed to regulate the cell cycle via the PKA/activating transcription factor 1 (ATF-1)/-catenin/cyclin D1 pathway, thereby enhancing proliferation of -cell [34]