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Low Dose Semaglutide Does Not Impair Skeletal Muscle Function in ZSF1 Obese Rats While GLP-1RAs, including semaglutide, have been linked to loss of lean muscle mass in obesity treatment 80,81 , the long-term clinical implications of this effect on quality of life and morbidity, particularly in the context of HFpEF 82 , remain unclear

Additionally, report any changes in digestion, persistent constipation, or new nutritional symptoms immediately, as these may signal the need for dose adjustment or additional dietary support

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