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Small molecules inhibiting ferroptosis by activating the Nrf2 pathway Nrf2 is a well-established transcription factor crucial for antioxidant defense

Found in virtually every cell in the human body, glutathione serves as our primary intracellular antioxidant, protecting cells from oxidative damage caused by free radicals, environmental toxins, and metabolic processes

For example, studies have found that triple-negative breast cancer (TNBC) competes for Gln uptake in the environment, limiting Gln metabolism in tumor-infiltrating T cells and inhibiting anti-tumor responses

Complete fractures involve a full break through the rib bone, sometimes with displacement