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It significantly ameliorates high-fat diet-induced structural dysbiosis of the gut microbiota by reducing the abundance of harmful bacteria positively correlated with hepatic lipid deposition (e.g., Lachnospiraceae and Collinsella) and increasing the abundance of beneficial bacteria (e.g., Ruminococcus and Turicibacter), thereby reducing hepatic lipogenesis and ultimately alleviates liver steatosis and lipid accumulation (Wang S

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Other CVOTs such as EXSCEL were designed to establish noninferiority with respect to safety and superiority with respect to efficacy

Studies show that when GLP-1 therapy is discontinued, much of the weight tends to return unless behavioral, nutritional, and metabolic foundations are simultaneously addressed