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The GWAS meta-analysis results for overall ovarian cancer, as well as subtype-specific GWAS results for EOC from the Ovarian Cancer Association Consortium (OCAC) 4 , were used as outcomes in the MR analyses (Supplementary Data 1)
Compared with full basal-bolus insulin regimens, the combination of GLP-1 agonist plus insulin resulted in a marginal 0.1% reduction in HbA1c, a 33% lower risk of hypoglycaemia and a mean 5.66-kg reduction in weight
Regarding metabolic inhibitors: HIF-1 inhibitors (e.g., PX-478) can specifically inhibit the enhancement of glycolysis and reduce the release of inflammatory factors (118, 119)
Many users find the symptoms subside over time as their digestive system adjusts
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