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Perturbations of this axis, such as oral dysbiosis or compromised barrier function, have been increasingly implicated in the pathogenesis of diverse systemic diseases, which involve three key mechanistic pathways of how localized oral events could exert distant effects ( Table 1 )

Intestinal barrier integrity plays a central role in the health and productivity of lactating dairy cows, particularly during periods of heat stress and metabolic strain

Research design and methods This study was approved by the Institutional Review Board of National Cheng Kung University (A-EX-106-013)