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The derivation from native hGH provides biological plausibility: the C-terminal region of growth hormone has been known since the 1990s to possess independent lipolytic activity separate from the growth-promoting effects mediated by intact GH and IGF-1 signaling

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Five patients (2%, 5/30) developed knee pain when taking five to seven tablets of penicillamine per day, but they were able to tolerate it by reducing the dose to three to six tablets per day

Collectively, these data illustrate that both early and late events occur, underscoring the necessity of long-term surveillance in MMNST