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Enrolling 17,604 adults aged 45 or older with established cardiovascular disease and a BMI of 27 or higher (without diabetes), SELECT showed that semaglutide 2.4 mg reduced the composite of cardiovascular death, nonfatal myocardial infarction, and nonfatal stroke by 20% over a mean follow-up of nearly 40 months

Signs you are ready to increase: Appetite suppression has noticeably decreased compared to earlier weeks at this dose Weight loss has stalled for 2+ weeks despite consistent diet and activity Gastrointestinal side effects from the current dose have resolved You have been at the current dose for at least 4 weeks Signs you should stay at your current dose longer: You are still losing weight consistently Appetite suppression remains effective You are experiencing ongoing nausea, vomiting, or fatigue Injection site reactions have not resolved Do not increase just because the schedule says to

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The rule in my lab is, if you discover it, you get to name itbut I have veto power, he told me