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Mechanisms of weight loss are multifactorial and independent of diabetes status, as seen in the SCALE Obesity and Prediabetes Study Group trial of GLP1RA in obese patients without diabetes, who lost 5.6 kg more weight than placebo (50)
According to the treatment-regimen estimand, HbA1c decreased by 1.23 percentage points with orforglipron 3 mg, 1.5 percentage points with orforglipron 12 mg and 1.56 percentage points with orforglipron 36 mg compared with a 0.81 percentage point decline with dapagliflozin at 40 weeks
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Combined, they create an optimal healing milieu where tissue repair, inflammation resolution, gut healing, cell growth, and immune regulation can all occur at once
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