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SARS-CoV-2 entry mechanism is mediated by the SPIKE protein (S protein) on the viral coat, which is comprised of two subunits: the S1 subunit containing the receptor binding domain (RBD) to ACE2, and the S2 subunit, responsible for membrane fusion

The available human data suggests significant regression toward baseline after discontinuation, which raises mechanistic questions about whether the compounds produce structural metabolic change or ongoing pharmacological modulation

Jaundice with high TSB levels is thought to be genotoxic

Atypical Spitzoid lesions appear to have minimal malignant potential in children [110]