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Silencing of NRF2 reduces the expression of ALDH1A1 and ALDH3A1 and sensitizes to 5-FU in pancreatic cancer cells

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In a diet-induced steatohepatitis mouse model with fructose exposure, retatrutide was associated with changes in hepatic triglycerides, cholesterol levels, alanine aminotransferase, and inflammatory markers, providing a useful system for studying how tri-agonist signaling influences liver biology in experimentally induced steatotic states [7]