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Studies have shown that these enzymes are transcriptionally regulated by sex hormone receptorsestrogen receptor (ER) and androgen receptor (AR)which mediate ferroptosis surveillance independent of GPX4 and FSP1 (Liang et al., 2023)

H., & Su Pang, J

Succinate-specific effects are initiated by epigenetic alterations through the inhibition of KDMs and the TET family 5mC hydroxylases, which induce the translation of tumorigenic genes (Fig