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A key restraint is the high annual cost of therapy, which can limit access for cash-paying patients and strain healthcare budgets, potentially leading to strict prior authorization or step-edit policies from payers that hinder prescription flow

Across technical and preclinical contexts, these peptides are referenced for educational and research purposes only, with emphasis on analytical handling, standardized protocols, and pathway-focused investigation under appropriately controlled conditions

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Longer-term citrulline interventions enhanced flow-mediated dilation after meals, hinting that IV delivery might extend such benefits, though this remains to be tested clinically