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Lipoprotein receptor-related protein (LRP) also known as LDLR, expressed in neurons, astrocytes, and endothelial cells in the brain functions as a receptor for tPA, mediating MMP upregulation, which in turn can contribute to hemorrhagic transformation from degradation of the neurovascular matrix (Lee et al., 2012)
The use of electronic health record data may not have captured all reasons for discontinuation, and insurance status was not directly analyzed
So potent anti-hypertension effects as well, presumably driven by such excessive weight loss
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