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Although these species are generated during normal cellular metabolism and participate in essential physiological processes like signal transduction and gene expression at low concentrations (Krishnamurthy et al., 2024), their excessive accumulation or insufficient scavenging leads to oxidative stress, causing damage to vital biomolecules and cellular structures
FOXO4-DRI reduces chemotherapy-induced senescence and chemotoxicity and cellular senescence in p16-positive aging XpdTTD/TTD mice 11
Patients were mainly screened at two primary care settings although advertisement was also used for dissemination of the study
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