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Relative contraindications requiring caution include active or suspected cancer (GHK-Cu promotes angiogenesis with concern about theoretically feeding tumors, though conflicting data shows documented anti-cancer gene expression effects requiring medical supervision), severe organ dysfunction (kidney or liver failure may slow peptide clearance), hemochromatosis or copper overload conditions, autoimmune disorders, and patients on immunosuppressants or blood thinners
Collectively, these observations position AOD 9604 as a selective modulator of adipose tissue signaling, enabling detailed study of receptor-mediated lipid metabolism and downstream cellular responses in controlled experimental models
Mar Drugs 16:125 Xie X, Zhou W, Hu Y, Chen Y, Zhang H, Li Y (2018) A dual-function epidermal growth factor receptor pathway substrate 8 (Eps8)-derived peptide exhibits a potent cytotoxic T lymphocyte-activating effect and a specific inhibitory activity