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While this approach is appropriate for capturing early oxidative and micronutrient-related alterations associated with disease severity, it does not allow evaluation of temporal dynamics, recovery patterns, or causal relationships, which would require longitudinal follow-up

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J Contemp Dent Pract 4:7686 Meleti M, Vescovi P, Mooi WJ et al (2008) Pigmented lesions of the oral mucosa and perioral tissues: a flow-chart for the diagnosis and some recommendations for the management