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the TCA or Krebs cycle)

Systemic administration of therapeutics also results in off-target effects, as only a small fraction of the administered dose crosses the BBB, with the remainder accumulating and affecting peripheral tissues 71,72

[DOI] [PMC free article] [PubMed] [Google Scholar] 139.Raz L, Bhaskar K, Weaver J, Marini S, Zhang Q, Thompson JF